华西口腔医学杂志 ›› 2016, Vol. 34 ›› Issue (6): 643-646.doi: 10.7518/hxkq.2016.06.018

• 综述 • 上一篇    下一篇

变异链球菌毒力相关转录调节因子的研究进展

李蓝1,张博文2,李继遥1   

  1. 1.口腔疾病研究国家重点实验室 华西口腔医院牙体牙髓病科(四川大学);2.头颈肿瘤外科,成都 610041
  • 收稿日期:2015-10-12 修回日期:2016-09-10 出版日期:2016-12-01 发布日期:2016-12-01
  • 通讯作者: 李继遥,教授,博士,E-mail:jiyao_li@aliyun.com
  • 作者简介:李蓝,硕士,E-mail:568598025@qq.com
  • 基金资助:
    国家自然科学基金面上项目(81371135)

Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence

Li Lan1, Zhang Bowen2, LiJiyao1   

  1. 1. State Key Laboratory of Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospitalof Stomatology, Sichuan University, Chengdu 610041, China; 2. State Key Laboratory of Oral Diseases, Dept. of Head andNech Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)Supported by: The National Natural Science Foundation of China (81371135). Correspondence: Li Jiyao, E-mail: jiyao_li@aliyun.com.
  • Received:2015-10-12 Revised:2016-09-10 Online:2016-12-01 Published:2016-12-01

摘要: 研究发现众多转录调节因子参与调节变异链球菌耐酸性等关键致龋毒力因子的表达,虽然仍有许多转录调节因子的作用靶点和调控机制尚不明确,但已有学者针对变异链球菌个别宏观转录调控因子进行单基因突变研究。本文就已发现的影响变异链球菌致龋毒力因子表达的调节因子及其功能和可能的作用机制进行综述。

关键词: 变异链球菌, 致龋毒力, 转录调节因子

Abstract: Some transcriptional regulators contribute to the expression of Streptococcus mutans (S. mutans) cariogenicvirulence factors. Although the target sequence transcriptional regulators anchored on the cell wall and the molecular mechanismof the regulation of S. mutans are yet to be clarified, certain global regulators potentially associated with the cariogenicityof S. mutans have been identified. This review is about these related transcriptional regulators, their function, and possiblemechanisms.

Key words: Streptococcus mutans, cariogenic virulence, transcriptional regulator

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