华西口腔医学杂志

• 基础研究 • 上一篇    下一篇

含精氨酸的抗敏抛光膏对暴露牙本质表面变异链球菌黏附的影响

刘音辰付东杰黄翠裴丹丹孙华岭1   

  1. 1.武汉大学口腔医学院口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室;2.武汉大学口腔医院修复科,武汉 4300793.西安交通大学口腔医院修复科,西安 710004
  • 收稿日期:2013-01-11 修回日期:2013-06-20 出版日期:2013-10-01 发布日期:2013-10-01
  • 通讯作者: 黄翠,Tel:027-87686130
  • 作者简介:刘音辰(1988—),女,湖南人,博士
  • 基金资助:

    国家自然科学基金资助项目(81070852,81171010)

Effect of an arginine-containing polishing paste on Streptococcus mutans adhesion to exposed dentin surfaces

Liu Yinchen1, Fu Dongjie1, Huang Cui2, Pei Dandan3, Sun Hualing1.   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School of Stomatology, Wuhan University, Wuhan 430079, China; 2. Dept. of Prosthodontics, Hospital of Stomatology, Wuhan University, Wuhan 430079, China; 3. Dept. of Prosthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
  • Received:2013-01-11 Revised:2013-06-20 Online:2013-10-01 Published:2013-10-01

摘要:

目的  研究含精氨酸抗敏抛光膏对暴露牙本质表面变异链球菌黏附的影响。方法  暴露牙本质小管,使用浮石粉和抗敏抛光膏处理表面,观察其粗糙度的变化。体外培养变异链球菌,观察其在牙本质片表面黏附及葡糖基转移酶(GTFs)基因表达情况。结果  使用浮石粉及抗敏抛光膏均能有效降低表面粗糙度,抗敏抛光膏处理后的牙本质能明显抑制gtfB和gtfC基因的表达。结论  含精氨酸抗敏抛光膏能抑制变异链球菌黏附及gtfB和gtfC基因的表达,对敏感牙本质区域龋病发生具有一定防治作用。

关键词: 精氨酸, 抛光膏, 黏附

Abstract:

Objective   To evaluate the effect of an arginine-containing antihypersensitivity polishing paste on Streptococ-cus mutans (S. mutans) adhesion to treated dentin. Methods   Dentin discs were treated with acid to expose dentin tubules, and then polished with either pumice or a polishing paste containing arginine. The surface roughness of the treated dentin was measured. The effects of dentin treatment on S. mutans adhesion and glucosyltransferase (GTFs) gene expression were also evaluated. Results   The surface roughness decreased after polishing with both pumice and arginine-containing polishing paste. Moreover, the polishing paste affected gtfB and gtfC expressions. Conclusion   The arginine-containing polishing paste affects S. mutans adhesion, as well as gtfB and gtfC expressions. The polishing paste may be used to prevent caries in exposed dentin areas.

Key words: arginine, polishing paste, adhesion