华西口腔医学杂志 ›› 2021, Vol. 39 ›› Issue (6): 709-711.doi: 10.7518/hxkq.2021.06.013

• 临床研究 • 上一篇    下一篇

预防性使用抗生素对唇裂术后伤口感染的影响研究

吴敏(), 朱祉冰, 石冰, 龚彩霞, 李杨()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院唇腭裂外科,成都 610041
  • 收稿日期:2020-07-20 修回日期:2021-09-02 出版日期:2021-12-01 发布日期:2021-12-03
  • 通讯作者: 李杨 E-mail:min-min-1984@163.com;luciaya@163.com
  • 作者简介:吴敏,主管护师,学士,E-mail:min-min-1984@163.com
  • 基金资助:
    国家自然科学基金青年基金项目(30900391)

Effect of the prophylactic use of antibiotics on wound infection after cleft lip surgery

Wu Min(), Zhu Zhibing, Shi Bing, Gong Caixia, Li Yang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-07-20 Revised:2021-09-02 Online:2021-12-01 Published:2021-12-03
  • Contact: Li Yang E-mail:min-min-1984@163.com;luciaya@163.com
  • Supported by:
    The National Natural Science Foundation of China Youth Fund Project(30900391)

摘要: 目的

研究术前预防性使用抗生素对唇裂术后患者伤口发生感染的影响。

方法

对2015年1月—2018年11月在四川大学华西口腔医院唇腭裂外科行一期唇裂修复术的1 361例患者的临床资料进行回顾性研究。将预防性使用抗生素和未预防性使用抗生素的患者分为两组。预防组594例患者,按裂隙类型分为单侧不完全型单纯唇裂(UICL)患者373例,单侧完全型单纯唇裂(UCCL)患者157例,双侧不完全型单纯唇裂(BICL)患者25例,双侧完全型单纯唇裂(BCCL)患者39例。未预防组767例患者,按裂隙类型分为UICL患者482例,UCCL患者211例,BICL患者31例,BCCL患者43例。比较两组术前术后白细胞计数和体温与术后切口感染的关系。

结果

两组患者术前术后白细胞计数、体温相比差异均无统计学意义(P>0.05)。

结论

术前患者预防性使用抗生素对唇裂修复术后感染的发生无明显影响。

关键词: 抗生素, 唇裂, 伤口感染

Abstract: Objective

To study the effect of preoperative prophylactic use of antibiotics on wound infection in patients with cleft lip.

Methods

Aretrospective study was conducted on the clinical data of 1 361 patients who underwent one-stage cleft lip repair in the Department of Cleft Lip and Palate in West China Hospital of Stomatology, Sichuan University, from January 2015 to November 2018. The patients were divided into two groups according to whether prophylactic antibiotics were used or not. There were 594 patients in the prevention group, including 373 unilateral incomplete cleft lip (UICL) patients, 157 unilateral complete cleft lip (UCCL) patients, 25 bilateral incomplete cleft lip (BICL) patients, 39 bilateral complete cleft lip (BCCL) patients. There were 767 patients in the non-prophylactic group, including 482 UICL patients, 211 UCCL patients, 31 BICL patients, 43 BCCL patients. The relationship between preoperative and postoperative leukocyte count, preoperative and postoperative body temperature, and postoperative wound infection were compared between the two groups.

Results

No significant difference was observed in the leukocyte count and body temperature between both groups (P>0.05).

Conclusion

The preoperative prophylactic use of antibiotics has no significant effect on the incidence of postoperative infection in patients undergoing cleft lip repair.

Key words: antibiotics, cleft lip, wound infection

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