华西口腔医学杂志 ›› 2020, Vol. 38 ›› Issue (4): 431-437.doi: 10.7518/hxkq.2020.04.014

• 综述 • 上一篇    下一篇

白色念珠菌对口腔黏膜疾病恶性转化作用的研究进展

廖敏(), 程磊, 周学东, 任彪()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科,成都 610041
  • 收稿日期:2019-01-07 修回日期:2020-05-19 出版日期:2020-08-01 发布日期:2020-08-03
  • 通讯作者: 任彪 E-mail:renbiao@scu.edu.cn
  • 作者简介:廖敏,硕士,E-mail: 568968964@qq.com
  • 基金资助:
    国家自然科学基金(81870778)

Research progress of Candida albicans on malignant transformation of oral mucosal diseases

Liao Min(), Cheng Lei, Zhou Xuedong, Ren Biao()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-01-07 Revised:2020-05-19 Online:2020-08-01 Published:2020-08-03
  • Contact: Ren Biao E-mail:renbiao@scu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(81870778)

摘要:

口腔癌是头颈部最常见的恶性肿瘤,也是全世界十大最流行的恶性病损之一。口腔微生物感染是口腔癌重要的危险因素。白色念珠菌作为口腔最常见的机会性致病真菌,大量流行病学资料证实,白色念珠菌感染与口腔黏膜恶变存在密切联系,而相关动物实验也证实,白色念珠菌感染能促进上皮癌变。现有研究表明,白色念珠菌可能的促癌机制涉及破坏上皮屏障、产生致癌物质(包括亚硝胺、乙醛)、诱导慢性炎症反应、激活免疫反应等。然而,目前关于这些机制的深入研究还不够充分,一些假说尚存在一定的争议。因此,本文就目前白色念珠菌对口腔黏膜疾病恶性转化作用的相关研究成果作一综述,为进一步的研究和临床口腔癌的防治工作提供参考。

关键词: 白色念珠菌, 口腔癌, 亚硝胺, 乙醛, 炎症反应, 白细胞介素-17

Abstract:

Oral cancer is the most common malignant tumor in the head and neck, and is one of the world’s top ten malignancies. Microbial infection is an important risk factor of oral cancer. Candida albicans is the most popular opportunistic fungal pathogen. Epidemiological studies have shown that Candida albicans is closely tied to oral malignancy. Animal experimentation have also proven that infection of Candida albicans can promote the development of oral epithelial carcinogenesis. The current studies have revealed several mechanisms involved in this process, including destroying the epithelial barrier, producing carcinogenic substances (nitrosamines, acetaldehyde), inducing chronic inflammation, activating immune response, etc. However, current researches on mechanisms are still inadequate, and some hypotheses remain controversial. Here, we review the findings related to Candida albicans’ effect on the malignant transformation of oral mucosa, hoping to provide reference for deep research and controlling oral cancer clinically.

Key words: Candida albicans, oral cancer, nitrosamines, acetaldehyde, inflammation, interleukin-17

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