牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用及机制

doi:10.7518/hxkq.2019.05.013

摘要/Abstract

摘要：

消化系统恶性肿瘤包括口腔癌、结直肠癌、胰腺癌、食管癌等多种疾病,是常见的高致死性恶性肿瘤。牙龈卟啉单胞菌作为牙周病最主要的致病菌,其致病性不仅仅发生在口腔,在消化系统其他部位也有不同的致病作用抑或是促进作用,其致病机制也逐渐受到研究者的重视。本文系统阐述了牙龈卟啉单胞菌在包括口腔癌的消化系统恶性肿瘤中的作用,并对其可能的致病机制进行综述。

关键词: 牙龈卟啉单胞菌, 消化系统恶性肿瘤, 致病机制

Abstract:

The malignant tumors including oral cancer, colorectal cancer, pancreatic cancer, and esophageal cancer, of the digestive system are a common high-fatal malignancy. Porphyromonas gingivalis, as the most important pathogen of periodontal disease, has been gradually proved that its invasiveness occurs not only in the mouth but also in other parts of the digestive system. Moreover, the relevant pathogenic mechanism is increasingly attracting the reseachers’ attention. In this study, the role and possible pathogenesis of Porphyromonas gingivalis in the digestive system are described in a systematic and comprehensive way.

Key words: Porphyromonas gingivalis, digestive system malignancy, pathogenic mechanism

中图分类号:

R780.2

王春萌,洪丽华,张志民,王渝. 牙龈卟啉单胞菌在消化系统恶性肿瘤中的作用及机制[J]. 华西口腔医学杂志, 2019, 37(5): 521-526.

Wang Chunmeng,Hong Lihua,Zhang Zhimin,Wang Yu. Research progress on the relationship between Porphyromonas gingivalis and the malignancy of the digestive system and possible pathogenetic mechanism[J]. West China Journal of Stomatology, 2019, 37(5): 521-526.

参考文献 48

[1]	Siegel RL, Miller KD, Jemal A . Cancer statistics, 2017[J]. CA Cancer J Clin, 2017,67(1):7-30.
[2]	Ahn J, Segers S, Hayes RB . Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality[J]. Carcinogenesis, 2012,33(5):1055-1058.
[3]	Kim SS, Ruiz VE, Carroll JD , et al. Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma[J]. Cancer Lett, 2011,305(2):228-238.
[4]	Nagaraja V, Eslick GD . Systematic review with meta-analysis: the relationship between chronic Salmonella typhicarrier status and gall-bladder cancer[J]. Aliment Pharmacol Ther, 2014,39(8):745-750.
[5]	Castellarin M, Warren RL, Freeman JD , et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma[J]. Genome Res, 2012,22(2):299-306.
[6]	Sutcliffe S, Giovannucci E, Isaacs WB , et al. Acne and risk of prostate cancer[J]. Int J Cancer, 2007,121(12):2688-2692.
[7]	Chaturvedi AK, Gaydos CA, Agreda P , et al. Chlamydia pneumoniae infection and risk for lung cancer[J]. Cancer Epidemiol Biomarkers Prev, 2010,19(6):1498-1505.
[8]	Hajishengallis G, Lamont RJ . Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology[J]. Mol Oral Microbiol, 2012,27(6):409-419.
[9]	Lalla E, Papapanou PN . Diabetes mellitus and periodontitis: a tale of two common interrelated diseases[J]. Nat Rev Endocrinol, 2011,7(12):738-748.
[10]	Tonetti MS . Periodontitis and risk for atherosclerosis: an update on intervention trials[J]. J Clin Periodontol, 2009,36(Suppl 10):15-19.
[11]	Sharma N, Shamsuddin H . Association between respiratory disease in hospitalized patients and periodontal disease: a cross-sectional study[J]. J Periodontol, 2011,82(8):1155-1160.
[12]	Zhang X, Zhang D, Jia HX , et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment[J]. Nat Med, 2015,21(8):895-905.
[13]	Rakoto-Alson S, Tenenbaum H, Davideau JL . Periodontal diseases, preterm births, and low birth weight: findings from a homogeneous cohort of women in Madagascar[J]. J Periodontol, 2010,81(2):205-213.
[14]	Dietrich T, Jimenez M, Krall Kaye EA , et al. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease[J]. Circulation, 2008,117(13):1668-1674.
[15]	Sfyroeras GS, Roussas N, Saleptsis VG , et al. Association between periodontal disease and stroke[J]. J Vasc Surg, 2012,55(4):1178-1184.
[16]	Suvan J, D’Aiuto F, Moles DR , et al. Association between overweight/obesity and periodontitis in adults. A systematic review[J]. Obes Rev, 2011,12(5):e381-e404.
[17]	Yuan X, Liu Y, Kong J , et al. Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract[J]. Cancer Lett, 2017,404:1-7
[18]	Nagy KN, Sonkodi I, Szöke I , et al. The microflora associated with human oral carcinomas[J]. Oral Oncol, 1998,34(4):304-308.
[19]	Katz J, Onate MD, Pauley KM , et al. Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma[J]. Int J Oral Sci, 2011,3(4):209-215.
[20]	Ha NH, Woo BH, Kim DJ , et al. Prolonged and repetitive exposure to Porphyromonas gingivalis increases aggressiveness of oral cancer cells by promoting acquisition of cancer stem cell properties[J]. Tumor Biol, 2015,36(12):9947-9960.
[21]	Ha NH, Park DG, Woo BH , et al. Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs[J]. Cytokine, 2016,86:64-72.
[22]	Woo BH, Kim DJ, Choi JI , et al. Oral cancer cells sustainedly infected with Porphyromonas gingivalis exhibit resistance to Taxol and have higher metastatic potential[J]. Oncotarget, 2017,8(29):46981-46992.
[23]	Abnet CC, Qiao YL, Mark SD , et al. Prospective study of tooth loss and incident esophageal and gastric cancers in China[J]. Cancer Causes Control, 2001,12(9):847-854.
[24]	Gao S, Li S, Ma Z , et al. Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer[J]. Infect Agent Cancer, 2016,11:3.
[25]	Gao SG, Yang JQ, Ma ZK , et al. Preoperative serum immunoglobulin G and A antibodies to Porphyromonas gingivalis are potential serum biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma[J]. BMC Cancer, 2018,18(1):17.
[26]	Michaud DS, Joshipura K, Giovannucci E , et al. A prospective study of periodontal disease and pancreatic cancer in US male health professionals[J]. J Natl Cancer Inst, 2007,99(2):171-175.
[27]	Michaud DS, Izard J, Wilhelm-Benartzi CS , et al. Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study[J]. Gut, 2013,62(12):1764-1770.
[28]	Jacob JA . Study links periodontal disease bacteria to pancreatic cancer risk[J]. JAMA, 2016,315(24):2653-2654.
[29]	Jan MS, Chen WT, Chen YJ , et al. Abstract 235: probiotics ameliorate Porphyromonas gingivalis-promoted pancreatic cancer progression in oncogenic Kras transgenic mice[J]. Cancer Res, 2017,77(13 Suppl):235.
[30]	Momen-Heravi F, Babic A, Tworoger SS , et al. Periodontal disease, tooth loss and colorectal cancer risk: results from the Nurses’ Health Study[J]. Int J Cancer, 2017,140(3):646-652.
[31]	王晴萱, 刘俊超, 潘亚萍 . 具核梭杆菌调控牙龈卟啉单胞菌感染对口腔鳞状细胞癌KB细胞周期和细胞因子分泌的研究[J]. 口腔医学研究, 2016,32(3):211-215.
	Wang QX, Liu JC, Pan YP . Impact of Fusobacterium nucleatum and Porphyromonas gingivalis modulation on the cell cycle and cytokines production of KB cells[J]. J Oral Sci Res, 2016,32(3):211-215.
[32]	Lin FY, Huang CY, Lu HY , et al. The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization[J]. Mol Oral Microbiol, 2015,30(3):198-216.
[33]	Natalwala A, Spychal R, Tselepis C . Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract[J]. World J Gastroenterol, 2008,14(24):3792.
[34]	Sztukowska MN, Ojo A, Ahmed S , et al. Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells[J]. Cell Microbiol, 2016,18(6):844-858.
[35]	Ramos-Junior ES, Morandini AC, Almeida-da-Silva CLC , et al. A dual role for P2X7 receptor during Porphyromonas gingivalis infection[J]. J Dent Res, 2015,94(9):1233-1242.
[36]	Lee J, Roberts JS, Atanasova KR , et al. A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27[J]. Cell Microbiol, 2018,20(5):e12825.
[37]	Yao L, Jermanus C, Barbetta B , et al. Porphyromonas gingivalis infection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells[J]. Mol Oral Microbiol, 2010,25(2):89-101.
[38]	Moffatt CE, Lamont RJ . Porphyromonas gingivalis induction of MicroRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells[J]. Infect Immun, 2011,79(7):2632-2637.
[39]	吴武超, 吴亚菲, 赵蕾 . 牙龈卟啉单胞菌与口腔鳞状细胞癌关系的研究进展[J]. 华西口腔医学杂志, 2015,33(6):651-655. doi: 10.7518/hxkq.2015.06.021
	Wu WC, Wu YF, Zhao L . Research progress on the relationship between Porphyromonas gingivalis and oral squamous cell carcinoma[J]. West China J Stomatol, 2015,33(6):651-655. doi: 10.7518/hxkq.2015.06.021
[40]	Kuboniwa M, Hasegawa Y, Mao S , et al. P. gingivalis accelerates gingival epithelial cell progression through the cell cycle[J]. Microbes Infect, 2008,10(2):122-128.
[41]	Gu ZD, Li JY, Li M , et al. Matrix metalloproteinases expression correlates with survival in patients with esophageal squamous cell carcinoma[J]. Am J Gastroenterol, 2005,100(8):1835-1843.
[42]	Groeger S, Jarzina F, Domann E , et al. Porphyromonas gingivalis, activates NFκB and MAPK pathways in human oral epithelial cells[J]. BMC Immunol, 2017,18(1):1.
[43]	Inaba H, Amano A, Lamont RJ , et al. Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis[J]. Med Microbiol Immunol, 2015,204(5):605-612.
[44]	Inaba H, Sugita H, Kuboniwa M , et al. Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation[J]. Cell Microbiol, 2014,16(1):131-145.
[45]	Groeger S, Jarzina F, Mamat U , et al. Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions[J]. Immunobiology, 2017,222(2):137-147.
[46]	Zaki MH, Boyd KL, Vogel P , et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis[J]. Immunity, 2010,32(3):379-391.
[47]	Aymeric L, Apetoh L, Ghiringhelli F , et al. Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity[J]. Cancer Res, 2010,70(3):855-858.
[48]	Baba Y, Iwatsuki M, Yoshida N , et al. Review of the gut microbiome and esophageal cancer: pathogenesis and potential clinical implications[J]. Ann Gastroenterol Surg, 2017,1(2):99-104.