软骨细胞外基质在软骨组织工程中的研究进展

doi:10.7518/hxkq.2019.02.016

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (2): 220-223.doi: 10.7518/hxkq.2019.02.016

软骨细胞外基质在软骨组织工程中的研究进展

李云洁¹,赵艳红¹(),杨强²

1.天津医科大学口腔医院正畸科,天津 300070
2.天津医院脊柱外科,天津 300211

收稿日期:2018-07-05 修回日期:2018-11-02 出版日期:2019-04-01 发布日期:2019-04-28
通讯作者: 赵艳红 E-mail:leafzh@126.com
作者简介:李云洁,硕士,E-mail： 250883893@qq.com
基金资助:
国家自然科学基金(31300798);国家自然科学基金(31470937);国家自然科学基金(81572154);天津市卫生局科技攻关重点项目(15KG125);天津市卫生局科技攻关重点项目(16KG114)

Development of cartilage extracellular matrix in cartilage tissue engineering

Yunjie Li¹,Yanhong Zhao¹(),Qiang Yang²

1.Dept. of Orthodontics, Stomatological Hospital of Tianjin Medical University, Tianjin 300070, China
2.Dept. of Spine Surgery, Tianjin Hospital, Tianjin 300211, China

Received:2018-07-05 Revised:2018-11-02 Online:2019-04-01 Published:2019-04-28
Contact: Yanhong Zhao E-mail:leafzh@126.com
Supported by:
The National Natural Science Foundation of China(31300798);The National Natural Science Foundation of China(31470937);The National Natural Science Foundation of China(81572154);The Research Foundation of Tianjin Health Bureau(15KG125);The Research Foundation of Tianjin Health Bureau(16KG114)

摘要/Abstract

摘要：

软骨组织工程是修复软骨缺损的有效方式,需要理想的支架材料促进干细胞发挥再生性能。软骨细胞外基质（CECM）能够有效地模仿软骨细胞生存环境,不仅对软骨细胞和干细胞具有良好的生物相容性,满足支架材料的基本要求,还能够促进软骨细胞分泌基质和诱导干细胞向软骨细胞分化,是一种极具优势的支架材料。CECM良好的促基质分泌和诱导分化作用与其含有多种软骨相关蛋白有关。在实际应用中,CECM存在力学性能不强和细胞渗透不足等问题,联合其他材料能在一定程度上弥补其不足,因此寻找性能更加优化的复合方式是CECM的应用趋势。本文对CECM材料在软骨组织工程中的研究进展作一综述。

关键词: 软骨细胞外基质, 软骨组织工程, 软骨再生, 干细胞

Abstract:

Cartilage tissue engineering, an effective way to repair cartilage defects, requires an ideal scaffold to promote the regeneration performance of stem cells. Cartilage extracellular matrix (CECM) can imitate the living environment of cartilage cells to the greatest extent. CECM not only exhibits good biocompatibility with chondrocytes and stem cells, which can meet the basic requirements of scaffolds, but also promotes chondrocytes to secrete matrix and induce stem cells to differentiate into chondrocytes; as such, this matrix is a better scaffold and has more advantages than existing ones. The promotion and induction effects could be related to various cartilage-related proteins inside. However, the practical application of this technique is hindered by problems, such as poor mechanical properties and insufficient cell penetration of CECM. Association with other materials can compensate for these inadequacies to a certain degree, and finding a combination mode with optimized performance is the application trend of CECM. This review focuses on research of CECM materials in cartilage tissue engineering.

Key words: cartilage extracellular matrix, cartilage tissue engineering, cartilage regeneration, stem cells

中图分类号:

R783

李云洁,赵艳红,杨强. 软骨细胞外基质在软骨组织工程中的研究进展[J]. 华西口腔医学杂志, 2019, 37(2): 220-223.

Yunjie Li,Yanhong Zhao,Qiang Yang. Development of cartilage extracellular matrix in cartilage tissue engineering[J]. West China Journal of Stomatology, 2019, 37(2): 220-223.

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软骨细胞外基质在软骨组织工程中的研究进展

Development of cartilage extracellular matrix in cartilage tissue engineering

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