人乳头瘤病毒相关头颈肿瘤的中文文献研究现状分析

doi:10.7518/hxkq.2017.03.014

摘要/Abstract

摘要：

目的基于目前国内人乳头瘤病毒（HPV）相关的头颈肿瘤的文献,结合国外文献研究,分析目前我国在此领域的研究现状。方法计算机检索四川大学图书馆电子期刊数据库,包括中国生物医学文献数据库（CBM）、维普中文科技期刊数据库（VIP）和万方期刊全文数据库,筛选并提取数据,分析国内与HPV相关的头颈肿瘤研究的基本特征、HPV总检出率以及不同临床病理指标对HPV感染的影响。结果国内头颈肿瘤患者中,HPV总检出率为34.05%。在分析不同临床病理指标对口腔鳞癌患者HPV感染的影响时,不吸烟组、不饮酒组的HPV感染率高于吸烟组（P=0.002）、饮酒组（P<0.005）;N2~N3期的HPV检出率高于N0~N1期（P=0.027）。结论 HPV相关头颈肿瘤的中文文献多数以临床研究为主,未来应继续研究致病的分子病理机制以及预后的分子信号通路,更多关注具有前瞻视角的治疗型HPV疫苗和分子靶向的研究。

关键词: 人乳头瘤病毒, 头颈肿瘤, 回顾性研究

Abstract:

Objective To analyze the current status of research on human papillomavirus (HPV)-associated head and neck cancers in China using national and international references. Methods We searched for bibliographies in the electronic databases of Sichuan University, including Chinese Biological and Medical Database (CBM), China Science and Technology Journal Database (VIP), and Wanfang Journal Database. Then, data was selected and extracted to analyze the basic characteristics of HPV-related head and neck cancers, the general prevalence of HPV, and the effects of various clinic pathological indicators on HPV patients. Results The general prevalence of HPV was 34.05% among civil patients with head and neck cancers. Our analysis of different clinical and pathological indices that affect HPV-associated oral squamous cell carcinomas revealed that non-smoking and non-drinking groups had higher HPV infection rates compared with smoking (P=0.002) and drinking (P<0.005) groups. In addition, N2-N3 stage patients had higher detectable rates than N0-N1 stage patients (P=0.027). Conclusion The majority of civil research studies on HPV-associated head and neck cancers are concentrated on clinical studies. Thus, the molecular neuropathology and signaling pathway of HPV should be further explored in the future to advance prognostic methods. Moreover, the perspective view of therapeutic vaccines and molecular-targeting treatments should receive close attention.

Key words: human papillomavirus, head and neck cancer, retrospective study

中图分类号:

R 739.8

刘琰, 曹鸣芯, 吴家顺, 高晓磊, 梁新华. 人乳头瘤病毒相关头颈肿瘤的中文文献研究现状分析[J]. 华西口腔医学杂志, 2017, 35(3): 301-310.

Yan Liu, Mingxin Cao, Jiashun Wu, Xiaolei Gao, Xinhua Liang. Analysis of the current status of research on human papillomavirus-associated head and neck cancers based on recent Chinese literature[J]. West China Journal of Stomatology, 2017, 35(3): 301-310.

图/表 2

表 1

纳入研究的基本特征

纳入文献	研究对象	样本量	样本来源	性别比例	检测方式	样本情况
纳入文献	所处地区	（n）	样本来源	（男/女）	检测方式	样本情况
张洋等^[12]	新疆	149	石蜡	81/68	RT-PCR	口腔鳞癌119例（舌体63例,牙龈37例,颊黏膜18例,
						硬腭1例）;口咽鳞癌20例（扁桃体3例,舌根12例,
						软腭3例,口咽部2例）;下咽鳞癌10例
杨波等^[13]	云南	55	石蜡	30/10*	原位杂交+免疫组织化学	头颈鳞癌40例（鼻咽7例,唇3例,口腔10例,下咽14
						例,皮肤6例）;头颈鳞状乳头状瘤10例;宫颈癌5例
马玲玲等^[14]	新疆	43	石蜡	40/3	原位杂交+免疫组织化学	喉癌22例;口咽癌6例;下咽癌15例
黄岸瑞等^[15]	广西	20	石蜡	20/0	原位杂交	下咽癌20例
何保昌等^[16]	福建	150	新鲜组织	87/63	基因芯片	口咽鳞癌75例;正常75例
张洁莉等^[17]	北京	78	石蜡	未报道	RT-PCR+原位杂交	头颈鳞癌78例（唇6例,口腔48例,口咽10例,下咽14
						例）
任晓勇等^[18]	陕西	113	石蜡	107/6	免疫组织化学	喉鳞癌78例;癌旁正常组织15例;声带息肉20例
薛万林等^[19]	湖北	35	石蜡	未报道	RT-PCR	口腔鳞癌30例;白斑5例
魏炜等^[20]	北京	9	石蜡	5/4	RT-PCR+免疫组织化学	唇鳞癌9例
王妍等^[21]	宁夏	79	石蜡	45/34	基因芯片	良性52例（混合瘤36例,腺瘤3例,腺淋巴瘤12例,肌
						上皮瘤1例）;恶性7例（腺癌3例,腺样囊性癌1例,黏
						液表皮样癌1例和其他2例）;正常口腔黏膜组织20例
黄辉等^[22]	北京	66	石蜡	61/5	SPF10-DNA线性杂交	口咽部鳞癌66例（腭扁桃体27例,舌根26例,软腭11
						例,咽后壁2例）
陈雪松等^[23]	北京	139	新鲜组织	未报道	第二代杂交捕获	头颈部癌139例（鼻咽107例,口咽10例,下咽12例,
						口腔2例,喉2例,其他6例）
马三成等^[24]	上海	157	石蜡	未报道	RT-PCR+免疫组织化学	口腔鳞癌73例;正常黏膜84例
陈亮等^[25]	江苏	92	石蜡	29/27*	免疫组织化学	口腔鳞癌56例;口腔白斑26例;正常口腔黏膜10例
姚姣利等^[26]	山西	180	石蜡+新鲜	34/6*	RT-PCR+免疫组织化学	石蜡喉癌40例,癌旁正常组织30例,声带息肉组织30
			组织			例;术中切除癌组织30例,癌旁正常织25例,声带
						息肉组织25例
吕彩凤等^[27]	重庆	84	石蜡	40/2*	免疫组织化学	石蜡喉癌42例;术中切除癌组织切缘42例
黄忠强等^[28]	广西	200	新鲜组织	未报道	RT-PCR	鼻咽癌150例;正常50例
叶青等^[29]	上海	121	石蜡	80/2*	免疫组织化学	喉鳞癌82例;非癌组织39例（息肉27例,癌周正常郪
						眽12例）
何爱娥^[30]	湖北	26	新鲜组织	未报道	RT-PCR	白斑6例;口腔鳞癌16例;正常黏膜4例
魏清跃等^[31]	广西	19	新鲜组织	未报道	RT-PCR+斑点杂交	口腔鳞癌19例
杨成等^[32]	湖北	82	石蜡	未报道	原位杂交	口腔鳞癌30例;白斑20例;正常30例;宫颈癌2例
李良忠等^[33]	新疆	78	石蜡	未报道	RT-PCR+免疫组织化学	口腔鳞癌66例;正常12例
郑红等^[34]	河南	36	新鲜组织	23/13	RT-PCR	口腔鳞癌20例;白斑16例
刘红等^[35]	北京	69	新鲜组织	未报道	RT-PCR	腮腺混合瘤25例;舌癌9例;颌骨肉瘤7例;涎腺恶性
						肿瘤15例;腺淋巴瘤6例;基底细胞腺瘤2例;腺泡细
						胞瘤2例;颌骨造釉细胞瘤3例
布静秋等^[36]	北京	55	石蜡	37/13*	原位杂交	口腔鳞癌50例;正常5例
王建广等^[37]	广东	60	新鲜组织	19/11*	RT-PCR	口腔鳞癌30例;正常30例
侯炜等^[38]	湖北	56	石蜡	未报道	RT-PCR	口腔鳞癌32例;白斑14例;正常10例
曹俊等^[39]	上海	60	石蜡	未报道	RT-PCR+免疫组织化学	口腔鳞癌40例;正常20例
陶震江等[40]	江苏	75	新鲜组织	24/21*	RT-PCR	良性肿瘤19例;恶性肿瘤26例（鳞癌18例,腺样囊性
						癌2例,恶性淋巴瘤2例,黏液表皮样癌1例,梭形内皮
						瘤1例,软骨肉瘤1例,血管滤泡型淋巴增生1例）;正
						常组织30例
高文涛等[41]	沈阳	80	石蜡	未报道	RT-PCR+免疫组织化学	舌鳞癌40例;正常40例
陈伟良等[42]	广东	42	新鲜组织	未报道	RT-PCR	口腔鳞癌21例;正常21例
向彬等[43]	辽宁	31	石蜡	未报道	免疫组织化学	口腔鳞癌31例（牙龈11例,舌9例,颊3例,口底4例,
						硬腭2例,咽旁及下颌骨原发性鳞癌各1例）
吴凯彦等[44]	河南	89	石蜡	未报道	原位杂交	喉乳头状瘤36例;喉鳞癌32例;声带息肉21例
李运良等[45]	湖南	41	石蜡+新鲜	未报道	RT-PCR	口腔鳞癌26例;正常15例
			组织
雷蕾等[46]	广东	33	石蜡+新鲜	17/6*	RT-PCR+Southern杂交	口腔鳞癌23例;正常10例
			组织
张桐等[47]	陕西	20	新鲜组织	未报道	RT-PCR+斑点杂交	恶性肿瘤10例（口腔鳞癌6例,腺样囊性癌2例,混合
						瘤1例,横纹肌肉瘤1例）;非肿瘤10例（唇裂5例,腭
						裂5例）
杨怀涛等[48]	四川	30	石蜡	未报道	RT-PCR	口腔鳞癌30例
刘学峰等[49]	湖北	40	新鲜组织	未报道	RT-PCR	头颈肿瘤40例（口腔癌11例,喉癌20例,喉乳头状瘤9
						例）

表 1

表 2

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