基质金属蛋白酶抑制剂的研究进展

doi:10.7518/hxkq.2017.02.019

摘要/Abstract

摘要：

牙本质粘接混合层的长期稳定性不佳,基质金属蛋白酶等内源性酶降解胶原是导致混合层破坏的重要因素。使用酶抑制剂抑制胶原降解,维持胶原结构的完整性,是提高混合层稳定性的关键。本文重点总结了基质金属蛋白酶抑制剂（包括氯己定、乙二胺四乙酸、季铵盐类、锌离子和氧化锌、四环素类及其衍生物、异羟肟酸类抑制剂、二磷酸盐衍生物、交联剂等）的研究进展,并对未来的发展进行展望。

关键词: 基质金属蛋白酶, 半胱氨酸组织蛋白酶, 牙本质, 酶抑制剂, 生物降解, 耐久性

Abstract:

Continuing advances in dentin bonding technology and adhesives revolutionized bonding of resin-based com-posite restorations. However, hybrid layers created by contemporary dentin adhesives present imperfect durability, and degra-dation of collagen matrix by endogenous enzymes is a significant factor causing destruction of hybrid layers. Bond durability can be improved by using enzyme inhibitors to prevent collagen degradation and to preserve integrity of collagen matrix. This review summarizes progress on matrix metalloproteinase inhibitors (including chlorhexidine, ethylenediaminetetraacetic acid, quaternary ammonium salt, tetracycline and its derivatives, hydroxamic acid inhibitors, bisphosphonate derivative, and cross-linking agents) and suggests prospects for these compounds.

Key words: matrix metalloproteinase, cysteine cathepsins, dentin, enzyme inhibitors, biodegradation, durability

中图分类号:

R783.2

贾玲玲, 万乾炳. 基质金属蛋白酶抑制剂的研究进展[J]. 华西口腔医学杂志, 2017, 35(2): 208-214.

Lingling Jia, Qianbing. Wan. Progress on matrix metalloproteinase inhibitors[J]. West China Journal of Stomatology, 2017, 35(2): 208-214.

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