华西口腔医学杂志

• 综述 • 上一篇    

口腔微生物与肿瘤关系的研究进展

葛阳 程磊 周学东   

  1. 口腔疾病研究国家重点实验室 华西口腔医院(四川大学),成都 610041
  • 出版日期:2014-10-01 发布日期:2014-10-01
  • 通讯作者: 周学东,教授,博士,E-mail:zhouxd@scu.edu.cn
  • 作者简介:葛阳,硕士,E-mail:yamy111@163.com
  • 基金资助:

    国家自然科学基金资助项目(81372889)

Research progress on the relationship between oral microbial community and tumor

Ge Yang, Cheng Lei, Zhou Xuedong.   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Online:2014-10-01 Published:2014-10-01

摘要:

口腔幽门螺杆菌与胃部肿瘤关系的研究,引发了对口腔微生物与肿瘤之间关系研究的热潮。本文从口腔幽门螺杆菌与胃部肿瘤的关系,口腔微生物群落与口腔鳞状细胞癌的关系,以及人类免疫缺陷病毒感染患者口腔微生物群落与肿瘤的特殊且密切的关系三个方面对口腔微生物群落与肿瘤之间的关系进行综述,对口腔微生物与肿瘤关系的进一步研究提供参考,以实现通过检测口腔微生物对肿瘤患者进行早期诊断,甚至辅助治疗的目的。

关键词: 口腔微生物群落, 口腔鳞状细胞癌, 人类免疫缺陷病毒, 幽门螺杆菌

Abstract:

Considering the World Health Organization’s classification of Helicobacter pylori as a definite (class Ⅰ) carcinogen, the relationship between oral microbial community and tumors is gaining increased interest. This review focused on three relationships between oral microbiota and tumors, i.e., between oral Helicobacter pylori infection and gastric tumors, between oral microbiota and oral squamous cell carcinoma, and between human immunodeficiency virus and tumors. The aims were to realize the early diagnosis of tumors with oral microbiota and support studies on treatment development.

Key words: oral microbial community, oral squamous cell carcinoma, human immunodeficiency virus, Helicobacter pylori