无托槽隐形矫治患者与固定矫治患者龈沟液中白细胞介素变化的对比研究

doi:10.7518/hxkq.2022.03.007

华西口腔医学杂志 ›› 2022, Vol. 40 ›› Issue (3): 293-296.doi: 10.7518/hxkq.2022.03.007

无托槽隐形矫治患者与固定矫治患者龈沟液中白细胞介素变化的对比研究

骆厚卓¹(), 方世殊¹, 刘倩¹, 党薇², 王艳丽³()

^1.空军军医大学口腔医院正畸科，西安 710032
^2.西安交通大学口腔医院修复科，西安 710004
^3.西安市中心医院口腔科，西安 710004

收稿日期:2021-09-27 修回日期:2021-11-10 出版日期:2022-06-01 发布日期:2022-06-01
通讯作者: 王艳丽 E-mail:zhuo361658708@126.com;xiatian1135@126.com
作者简介:骆厚卓，主治医师，硕士，E-mail：zhuo361658708@126.com
基金资助:
国家口腔疾病临床医学研究中心资助项目(LCA202009)

Comparison of interleukin expression in gingival crevicular fluid between patients with invisible orthodontics treat-ment and fixed orthodontics treatment

Luo Houzhuo¹(), Fang Shishu¹, Liu Qian¹, Dang Wei², Wang Yanli³()

^1.Dept. of Orthodontics, School of Stomatology, The Air Force Medical University, Xi’an 710032, China
^2.Dept. of Prosthodontics, College of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
^3.Dept. of Stomatology, Xi’an Central Hospital, Xi’an 710004, China

Received:2021-09-27 Revised:2021-11-10 Online:2022-06-01 Published:2022-06-01
Contact: Wang Yanli E-mail:zhuo361658708@126.com;xiatian1135@126.com
Supported by:
National Center for Clinical Medical Research on Oral Diseases(LCA202009);Correspondence: Wang Yanli, E-mail: xiatian1135@126.com

摘要/Abstract

摘要： 目的

对比无托槽隐形矫治患者与固定矫治患者治疗后龈沟液中白细胞介素（IL）-1β、IL-6、IL-8、IL-10、IL-16和IL-18的表达水平差异。

方法

选取接受无托槽隐形矫治的67例患者作为观察组，接受固定矫治的40例患者作为对照组，分别检测患者接受矫治前与接受矫治后24 h、12个月龈沟液中IL-1β、IL-6、IL-8、IL-10、IL-16和IL-18的表达水平。

结果

接受正畸治疗前2组龈沟液中各IL的表达水平差异无统计学意义（P>0.05）；正畸治疗24 h后2组龈沟液中的IL-1β、IL-6、IL-8、IL-10和IL-18表达水平均升高，但2组间所有IL因子表达水平差异无统计学意义（P>0.05）；正畸治疗12个月后观察组龈沟液中的IL-1β、IL-6、IL-8、IL-10和IL-18表达水平低于对照组（P<0.05），IL-16表达水平2组间差异无统计学意义（P>0.05）。

结论

与固定矫治相比，无托槽隐形矫治患者的口腔炎症反应较弱，更有利于口腔微环境的恢复。

关键词: 无托槽隐形矫治, 固定矫治, 白细胞介素, 炎症

Abstract: Objective

To compare the expression levels of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-16, and IL-18 in gingival crevicular fluid between patients with invisible orthodontics treatment and fixed orthodontics treatment.

Methods

A total of 67 patients with invisible orthodontic treatment were selected as the observation group, and 40 patients with fixed orthodontic treatment were selected as the control group. The expression levels of IL-1β, IL-6, IL-8, IL-10, IL-16, and IL-18 in gingival crevicular fluid before, 24 h, and 12 months after orthodontic treatment were detected.

Results

No significant difference in basic characteristics and interleukin expression levels in gingival crevicular fluid was observed between the two groups before orthodontic treatment (P>0.05). After 24 h of orthodontic treatment, the expression levels of IL-1β, IL-6, IL-8, IL-10, and IL-18 in gingival crevicular fluid increased in both groups; however, no significant difference was observed between the two groups (P>0.05). After 12 months of orthodontic treatment, the expression levels of IL-1β, IL-6, IL-8, IL-10, and IL-18 in gingival crevicular fluid in the observation group were significantly lower than those in the control group (P<0.05), and no significant difference in the expression level of IL-16 was observed between the two groups (P>0.05).

Conclusion

Compared with patients with fixed orthodontics treatment, those with invisible orthodontics treatment had weaker oral inflammatory response, which was conducive to the recovery of the oral microenvironment.

Key words: invisible orthodontics treatment, fixed orthodontics treatment, interleukin, inflammation

中图分类号:

R 783.5

骆厚卓, 方世殊, 刘倩, 党薇, 王艳丽. 无托槽隐形矫治患者与固定矫治患者龈沟液中白细胞介素变化的对比研究[J]. 华西口腔医学杂志, 2022, 40(3): 293-296.

Luo Houzhuo, Fang Shishu, Liu Qian, Dang Wei, Wang Yanli. Comparison of interleukin expression in gingival crevicular fluid between patients with invisible orthodontics treat-ment and fixed orthodontics treatment[J]. West China Journal of Stomatology, 2022, 40(3): 293-296.

图/表 3

表 1

表 2

表 3

参考文献 14

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项目	对照组	观察组	χ²/t值	P值
患者人数	67	40	/	/
性别（男/女）	39/28	24/16	0.586	0.682
年龄/岁	25±7	27±6	0.921	0.346
探诊深度/mm	1.41±0.31	1.44±0.29	0.396	0.844
IL-1β/（pg·mL^-1）	3.27±1.81	3.32±1.62	0.788	0.453
IL-6/（pg·mL^-1）	3.48±1.32	3.21±1.77	0.607	0.654
IL-8/（pg·mL^-1）	3.09±1.07	3.16±1.23	0.701	0.541
IL-10/（pg·mL^-1）	2.71±1.89	2.48±1.37	0.639	0.613
IL-16/（pg·mL^-1）	16.95±4.14	16.85±3.94	0.957	0.322
IL-18/（pg·mL^-1）	9.27±3.23	8.92±3.41	1.024	0.281

项目	对照组	观察组	t值	P值
IL-1β	6.31±1.34	6.57±1.51	0.88	0.38
IL-6	6.37±1.50	6.30±1.47	0.22	0.82
IL-8	5.96±1.12	5.86±2.34	0.23	0.81
IL-10	5.98±1.44	6.27±1.87	0.85	0.39
IL-16	16.42±3.43	16.05±3.84	0.49	0.62
IL-18	16.27±2.63	16.24±3.54	0.05	0.95

项目	对照组	观察组	t值	P值
IL-1β	3.32±1.34	2.42±1.12	3.69	0.01
IL-6	3.89±1.39	2.85±1.37	3.77	0.01
IL-8	3.36±1.12	2.26±1.21	4.67	0.01
IL-10	4.38±1.26	2.91±1.37	5.52	0.01
IL-16	16.42±0.54	16.27±0.29	0.26	0.79
IL-18	9.35±2.29	7.29±1.99	4.88	0.01

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无托槽隐形矫治患者与固定矫治患者龈沟液中白细胞介素变化的对比研究

Comparison of interleukin expression in gingival crevicular fluid between patients with invisible orthodontics treat-ment and fixed orthodontics treatment

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