浓缩生长因子对上颌前牙区种植骨增量术后反应的影响

doi:10.7518/hxkq.2019.04.011

华西口腔医学杂志 ›› 2019, Vol. 37 ›› Issue (4): 398-402.doi: 10.7518/hxkq.2019.04.011

浓缩生长因子对上颌前牙区种植骨增量术后反应的影响

于甜甜^1,^2,³,刘金^1,⁴,尹俊景^1,^2,⁵,许香娜^1,²,闫圣杰^1,²,兰晶^1,²()

1.山东省口腔组织再生重点实验室
2.山东大学口腔医学院·口腔医院种植科,济南 250012
3.烟台市口腔医院种植科,烟台 264008
4.山东大学口腔医学院·口腔医院修复科,济南 250012
5.河北医科大学口腔医院口腔颌面外科,石家庄 050017

收稿日期:2019-02-27 修回日期:2019-05-25 出版日期:2019-08-01 发布日期:2019-08-23
通讯作者: 兰晶 E-mail:kqlj@sdu.edu.cn
作者简介:于甜甜,住院医师,硕士,E-mail：ytttian@126.com
基金资助:
山东省自然科学基金(ZR2015HM065)

Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone

Tiantian Yu^1,^2,³,Jin Liu^1,⁴,Junjing Yin^1,^2,⁵,Xiangna Xu^1,²,Shengjie Yan^1,²,Jing Lan^1,²()

1.Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
2.Dept. of Implantology, School & Hospital of Stomatology, Shandong University, Jinan 250012, China
3.Dept. of Implantology, Yantai Stomatology Hospital, Yantai 264008, China
4.Dept. of Prosthodontics, School & Hospital of Stomatology, Shandong University, Jinan 250012, China
5.Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, China

Received:2019-02-27 Revised:2019-05-25 Online:2019-08-01 Published:2019-08-23
Contact: Jing Lan E-mail:kqlj@sdu.edu.cn
Supported by:
Natural Science Foundation of Shandong Province(ZR2015HM065)

摘要/Abstract

摘要：

目的研究浓缩生长因子（CGF）对种植骨增量患者术后疼痛和肿胀的作用。方法选择28例单颗上颌前牙缺失伴唇侧骨板缺损可同期植入种植体的患者,随机分为2组,每组14例,试验组应用CGF行引导骨再生术,对照组应用胶原膜行引导骨再生术,分析对比两组患者术后疼痛和肿胀程度。术后疼痛采用视觉模拟评分（VAS）法测定,肿胀程度根据肿胀范围划分4个等级。采用SPSS 23.0软件包对结果进行统计分析。结果试验组和对照组患者疼痛VAS评分分别为35.1±22.5和47.0±20.3,术后疼痛持续时间分别为（2.1±1.5）、（2.8±1.0） d,组间差异无统计学意义（P>0.05）。试验组无肿胀、轻度肿胀、中度肿胀、重度肿胀的百分比分别为21.4%、57.1%、21.4%、0,对照组依次为7.1%、35.7%、35.7%和21.4%,术后肿胀持续时间分别为（2.4±1.4）、（4.2±2.2） d,差异存在统计学意义（P<0.05）。结论 CGF的应用可以减轻患者术后肿胀程度,缩短术后肿胀时间,但对疼痛无明显作用。

关键词: 浓缩生长因子, 引导骨再生术, 术后反应

Abstract:

Objective To explore the effect of concentrated growth factors (CGF) on postoperative pain and swelling in patients with complex dental implants. Methods A total of 28 patients with single maxillary anterior teeth loss and labial orbital bone defect were recruited randomly and divided into two groups. Each group included 14 patients. The experimental group was applied with CGF membrane to guide bone regeneration, whereas the control group was treated with collagen membrane to guide bone regeneration. The postoperative pain degree and swelling degree were compared, and data were analyzed with SPSS 23.0 software. Postoperative pain was measured by visual analogue scale (VAS), and the degree of swelling was divided into four grades according to swelling range. Results VAS scores of patients in experimental and control groups reached 35.1±22.5 and 47.0±20.3, respectively. The duration of postoperative pain in experimental and control groups totaled (2.1±1.5) and (2.8±1.0) days, respectively. No statistically significant difference was observed between the two groups (P>0.05). Percentages of non-swelling, mild swelling, moderate swelling, and severe swelling in experimental group reached 21.4%, 57.1%, 21.4%, and 0, respectively, and those in control group were 7.1%, 35.7%, 35.7%, and 21.4%. Swelling duration reached (2.4±1.4) and (4.2±2.2) days in the experimental and control groups, respectively. A statistically significant difference was observed in the swelling degree of experimental and control groups (P<0.05). Conclusion The use of CGF can significantly reduce the degree of postoperative swelling and shorten swelling time but cause no significant effect on pain.

Key words: concentrated growth factors, guided bone regeneration, postoperative reaction

中图分类号:

R783

于甜甜,刘金,尹俊景,许香娜,闫圣杰,兰晶. 浓缩生长因子对上颌前牙区种植骨增量术后反应的影响[J]. 华西口腔医学杂志, 2019, 37(4): 398-402.

Tiantian Yu,Jin Liu,Junjing Yin,Xiangna Xu,Shengjie Yan,Jing Lan. Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone[J]. West China Journal of Stomatology, 2019, 37(4): 398-402.

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参考文献 21

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调查项目	项目分类
性别	A：男;B：女
年龄/岁	依据患者年龄填写
手术时长/min	依据手术记录填写
术后抗生素服用时间/d	A：0;B：<3;C：3~5（含3 d）;D：5~7（含5 d）;E：≥7
术后漱口水服用时间/d	A：0;B：<3;C：3~5（含3 d）;D：5~7（含5 d）;E：≥7
服用镇痛药物次数/次	A：0;B：1;C：2;D：3;E：4;F：5;G：6;H：7
术后疼痛评估（VAS评分）	根据疼痛程度记录VAS分值,0代表无疼痛,100代表难以忍受的剧痛
术后疼痛持续时间/d	A：0;B：1;C：2;D：3;E：4;F：5;G：6;H：7
术后肿胀范围	A：无肿胀;B：轻度,肿胀局限于鼻翼至两侧口角;C：中度,肿胀局限于瞳孔连线的垂直线内
	侧;D：重度,肿胀超过以上限度
术后肿胀持续时间/d	A：0;B：1;C：2;D：3;E：4;F：5;G：6;H：7
满意度评价（VAS评分）	根据满意程度记录VAS分值,0代表极不满意,100代表非常满意

组别	无肿胀	轻度肿胀	中度肿胀	重度肿胀
CGF	3/21.4	8/57.1	3/21.4	0/0
胶原膜	1/7.1	5/35.7	5/35.7	3/21.4

浓缩生长因子对上颌前牙区种植骨增量术后反应的影响

Effects of concentrated growth factors on relieving postoperative reaction of guided bone regeneration in the esthetic zone

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组别	VAS评分	疼痛时间/d	P值
CGF	35.1±22.5	2.1±1.5	0.156
胶原膜	47.0±20.3	2.8±1.0	0.182