微生态调节技术在感染性疾病预防中的应用

doi:10.7518/hxkq.2018.05.018

华西口腔医学杂志 ›› 2018, Vol. 36 ›› Issue (5): 564-567.doi: 10.7518/hxkq.2018.05.018

微生态调节技术在感染性疾病预防中的应用

王晖(),康迪,周学东,李雨庆()

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院,成都 610041

收稿日期:2018-03-05 修回日期:2018-05-30 出版日期:2018-10-01 发布日期:2018-10-18
作者简介:王晖,博士,E-mail： 1362268910@qq.com
基金资助:
国家自然科学基金(81430011);国家自然科学基金(31200985)

Prevention of infectious diseases through microecology modulation techniques

Hui Wang(),Di Kang,Xuedong Zhou,Yuqing Li()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hos-pital of Stomatology, Sichuan University, Chengdu 610041, China

Received:2018-03-05 Revised:2018-05-30 Online:2018-10-01 Published:2018-10-18
Supported by:
The National Natural Science Foundation of China(81430011);The National Natural Science Foundation of China(31200985)

摘要/Abstract

摘要：

人体共生微生物数量远超过人体自身细胞数量,其编码基因数量甚至是人类的数百倍。人体可以看做是微生物与自身细胞共同形成的复杂生态系统。这些分布在人体皮肤、呼吸道、口腔、胃肠道、泌尿生殖道等部位的微生物群落之间的动态平衡与人体健康息息相关。随着各国人体微生物研究计划的先后开展,引发了新一轮微生物组技术研究和开发的热潮。人体微生物群落生态调节的新工具、新方法和新技术正在大量出现,改善人体微生态和预防感染性疾病的手段将变得更加丰富。本文就目前已有的微生态调节技术在人类感染性疾病预防中的研究进展作一综述。

关键词: 人体微生物组, 微生态调节技术, 感染性疾病, 生态防治

Abstract:

The microbe is small in volume, but large in quantity and species. The symbiotic microbe, which is far more than human cells, code millions times of genes than human being. Somatic cells and these symbiotic microbe distributing in human body skin, respiratory tract, oral cavity and gastrointestinal tract, urinary tract and other parts form a complex ecosystem whose dynamic balance is highly related to body health. With the successful implementation of Human Microbiome Project, more attentions have been paid to the next generation microbiome technologies. New tools and methods for ecological regulation of human microbiome are emerging. The way we improve the world of human microbiology will be more convenient. This paper will make a review on the modulation techniques of human microbiome.

Key words: human microbiome, microecological regulation technology, infectious diseases, ecological prevention

中图分类号:

R781

王晖,康迪,周学东,李雨庆. 微生态调节技术在感染性疾病预防中的应用[J]. 华西口腔医学杂志, 2018, 36(5): 564-567.

Hui Wang,Di Kang,Xuedong Zhou,Yuqing Li. Prevention of infectious diseases through microecology modulation techniques[J]. West China Journal of Stomatology, 2018, 36(5): 564-567.

参考文献 30

[1]	Lederberg J, Mccray AT . ‘Ome Sweet’ Omics—A genealo-gical treasury of words[J]. Scientist, 2001,15(7):22-27.
[2]	Lynch SV, Pedersen O . The human intestinal microbiome in health and disease[J]. N Engl J Med, 2016,375(24):2369-2379. doi: 10.1056/NEJMra1600266 URL pmid: 27974040
[3]	周学东, 肖晓蓉 . 口腔微生物学[M]. 成都: 四川大学出版社, 2002: 210.
	Zhou XD, Xiao XR. Oral microbiology[M]. Chengdu: Sichuan University Press, 2002: 210.
[4]	Flemming HC, Wingender J, Szewzyk U , et al. Biofilms: an emergent form of bacterial life[J]. Nat Rev Microbiol, 2016,14(9):563-575. doi: 10.1038/nrmicro.2016.94 URL pmid: 27510863
[5]	戴自英 . 实用抗菌药物学[M]. 2版. 上海: 上海科学技术出版社, 1998: 23-24.
	Dai ZY. Practical antibacterial drugs[M]. 2nd ed. Shanghai: Shanghai Science and Technology Press, 1998: 23-24.
[6]	Palmer RJ Jr . Composition and development of oral bacterial communities[J]. Periodontol 2000, 2014,64(1):20-39. doi: 10.1111/j.1600-0757.2012.00453.x URL pmid: 3876289
[7]	Lloyd-Price J, Abu-Ali G, Huttenhower C . The healthy hu-man microbiome[J]. Genome Med, 2016,8(1):51. doi: 10.1186/s13073-016-0307-y URL
[8]	徐欣, 何金枝, 周学东 . 口腔微生物群落在口腔与全身疾病预警中的作用[J]. 华西口腔医学杂志, 2015,33(6):555-560. doi: 10.7518/hxkq.2015.06.001 URL
	Xin X, He JZ, Zhou XD . Oral microbiota: a promising pre-dictor of human oral and systemic diseases[J]. West Chin J Stomatol, 2015,33(6):555-560. doi: 10.7518/hxkq.2015.06.001 URL
[9]	Guo L, McLean JS, Yang Y , et al. Precision-guided antimi-crobial peptide as a targeted modulator of human microbial ecology[J]. Proc Natl Acad Sci U S A, 2015,112(24):7569-7574. doi: 10.1073/pnas.1506207112 URL pmid: 26034276
[10]	Koo H, Xiao J, Klein MI . Extracellular polysaccharides matrix—an often forgotten virulence factor in oral biofilm research[J]. Int J Oral Sci, 2009,1(4):229-234. doi: 10.4248/IJOS.09086 URL
[11]	Takahashi N, Nyvad B . The role of bacteria in the caries process: ecological perspectives[J]. J Dent Res, 2011,90(3):294-303. doi: 10.1177/0022034510379602 URL
[12]	Ren Z, Cui T, Zeng J , et al. Molecule targeting glucosyl-transferase inhibits Streptococcus mutans biofilm formation and virulence[J]. Antimicrob Agents Chemother, 2016,60(1):126-135. doi: 10.1128/AAC.00919-15 URL
[13]	Ren Z, Chen L, Li J , et al. Inhibition of Streptococcus mutans polysaccharide synjournal by molecules targeting glycosyl-transferase activity[J]. J Oral Microbiol, 2016,8:31095. doi: 10.3402/jom.v8.31095 URL
[14]	Xiao J, Zuo Y, Liu Y , et al. Effects of Nidus Vespae extract and chemical fractions on glucosyltransferases, adherence and biofilm formation of Streptococcus mutans[J]. Arch Oral Biol, 2007,52(9):869-875. doi: 10.1016/j.archoralbio.2007.02.009 URL
[15]	Xie Q, Li J, Zhou X . Anticaries effect of compounds extracted from Galla chinensis in a multispecies biofilm model[J]. Oral Microbiol Immunol, 2008,23(6):459-465.
[16]	Chu JP, Li JY, Hao YQ , et al. Effect of compounds of Galla chinensis on remineralisation of initial enamel carious lesions in vitro[J]. J Dent, 2007,35(5):383-387. doi: 10.1016/j.jdent.2006.11.007 URL
[17]	Thimothe J, Bonsi IA, Padilla-Zakour OI , et al. Chemical characterization of red wine grape (Vitis vinifera and Vitis interspecific hybrids) and pomace phenolic extracts and their biological activity against Streptococcus mutans[J]. J Agric Food Chem, 2007,55(25):10200-10207. doi: 10.1021/jf0722405 URL
[18]	慈向科, 陈丽培, 欧晓艳 . 葡萄籽原花青素对牙龈卟啉单胞菌内毒素的影响[J]. 上海口腔医学, 2015,24(4):433-436.
	Ci XK, Chen LP, Ou XY . Grape seed proanthocyanidin extracts inhibit lipopolysaccharide of Porphyromonas gin-givalis[J]. Shanghai J Stomatol, 2015,24(4):433-436.
[19]	Murakami Y, Kawata A, Ito S , et al. The radical scavenging activity and cytotoxicity of resveratrol, orcinol and 4-Allyl- phenol and their inhibitory effects on Cox-2 gene expres-sion and Nf-κB activation in RAW264.7 cells stimulated with Porphyromonas gingivalis-fimbriae[J]. In Vivo, 2015,29(3):341-349.
[20]	Muñoz-González I, Thurnheer T, Bartolomé B , et al. Red wine and oenological extracts display antimicrobial effects in an oral bacteria biofilm model[J]. J Agric Food Chem, 2014,62(20):4731-4737. doi: 10.1021/jf501768p URL
[21]	Furiga A, Lonvaud-Funel A, Badet C . In vitro study of antio-xidant capacity and antibacterial activity on oral anaerobes of a grape seed extract[J]. Food Chemistry, 2009,113(4):1037-1040. doi: 10.1016/j.foodchem.2008.08.059 URL
[22]	The Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome[J]. Nature, 2012,486(7402):207-214. doi: 10.1038/nature11234 URL
[23]	Brown JM, Hazen SL . The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases[J]. Annu Rev Med, 2015,66:343-359. doi: 10.1146/annurev-med-060513-093205 URL
[24]	Blanton LV, Charbonneau MR, Salih T , et al. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children[J]. Science, 2016, 351(6275): aad3311. doi: 10.1126/science.aad3311 URL
[25]	Suez J, Elinav E . The path towards microbiome-based me-tabolite treatment[J]. Nat Microbiol, 2017,2:17075. doi: 10.1038/nmicrobiol.2017.75 URL pmid: 28540921
[26]	Brandt LJ, Aroniadis OC . An overview of fecal microbiota transplantation: techniques, indications, and outcomes[J]. Gastrointest Endosc, 2013,78(2):240-249. doi: 10.1016/j.gie.2013.03.1329 URL pmid: 23642791
[27]	van der Oost J, Jore MM, Westra ER , et al. CRISPR-based adaptive and heritable immunity in prokaryotes[J]. Trends Biochem Sci, 2009,34(8):401-407. doi: 10.1016/j.tibs.2009.05.002 URL pmid: 19646880
[28]	Ledford H . CRISPR: gene editing is just the beginning[J]. Nature, 2016,531(7593):156-159. doi: 10.1038/531156a URL pmid: 26961639
[29]	Citorik RJ, Mimee M, Lu TK . Sequence-specific antimicro-bials using efficiently delivered RNA-guided nucleases[J]. Nat Biotechnol, 2014,32(11):1141-1145. doi: 10.1038/nbt.3011 URL pmid: 25240928
[30]	Qin N, Yang F, Li A , et al. Alterations of the human gut microbiome in liver cirrhosis[J]. Nature, 2014,513(7516):59-64. doi: 10.1038/nature13568 URL

微生态调节技术在感染性疾病预防中的应用

Prevention of infectious diseases through microecology modulation techniques

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