华西口腔医学杂志 ›› 2017, Vol. 35 ›› Issue (2): 187-191.doi: 10.7518/hxkq.2017.02.015

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人乳头瘤状病毒在头颈部鳞状细胞癌中的研究进展

崔广学1(), 高晓磊2, 梁新华2()   

  1. 1.赤峰学院附属医院口腔颌面外科,赤峰 024000
    2.口腔疾病研究国家重点实验室,国家口腔疾病临床研究中心,四川大学华西口腔医院口腔颌面外科,成都 610041
  • 收稿日期:2016-05-15 修回日期:2016-08-10 出版日期:2017-04-01 发布日期:2017-04-01
  • 作者简介:

    崔广学,主任医师,硕士,E-mail:cuiguangxuegood@163.com

  • 基金资助:
    国家自然科学基金(81361120399)

Role of human papillomavirus in head and neck squamous cell carcinomas

Guangxue Cui1(), Xiaolei Gao2, Xinhua Liang2()   

  1. 1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Chifeng University, Chifeng 024000, China
    2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-05-15 Revised:2016-08-10 Online:2017-04-01 Published:2017-04-01
  • Supported by:
    The National Natural Science Foundation of China (81361120399)

摘要:

高危型人乳头瘤状病毒是宫颈癌的主要致病因素,近年来研究发现人乳头瘤状病毒感染与头颈部鳞状细胞癌的发生也存在密切关系。本文对人乳头瘤状病毒相关性头颈部鳞状细胞癌的流行病学、致癌机制、诊断方法、治疗及预后等方面的研究进展作一综述。

关键词: 人乳头瘤状病毒, 头颈部鳞状细胞癌, 致癌基因

Abstract:

Human papillomavirus (HPV) is a major causative agent of cervical cancers. Over the past several decades, increasing number of studies established strong association of HPV with a subset of head and neck squamous cell carcinomas (HNSCCs). In the present study, we reviewed evidence, including epidemiology, carcinogens, diagnosis, treatment, and pro-gnosis, showing that HPV-positive HNSCCs exhibit a variety of distinct characteristics for understanding tumor biology and improving cancer treatment.

Key words: human papillomavirus, head and neck squamous cell carcinomas, carcinogene

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