关键词: 缺氧诱导因子-1α, 髁突软骨, 低氧, 静压力

Abstract: The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposedin normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in greatdifficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much aspossible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response tohypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes. This reviewsummarized current knowledge of the HIF-1α structure, signaling pathway, and mechanism of HIF-1α in the condylar cartilagerepair.

Key words: hypoxia-inducible factor-1α, condylar cartilage, hypoxic, static pressure