关键词: 牙周治疗, 心血管疾病, 牙周炎, Meta分析, 系统评价

Abstract:

Objective  To evaluate the efficacy of periodontal treatment for the management of cardiovascular risk fac-tors. Methods  Eligible studies in Cochrane Controlled Trials Register/CENTRAL, PubMed, EMBASE, and China Biology Medicine disc (CBMdisc) were searched until October 13, 2011. References of the included studies were hand searched. Two reviewers assessed the risk of bias and extracted the data of the included studies in duplicate. Meta-analysis was con-ducted with Revman 5.1. Results  Six randomized controlled trials involving 682 participants were included. One case had low risk of bias, another one had moderate risk of bias, and the remaining four had high risk of bias. Meta-analysis showed that periodontal treatment has no significant effect on C-reactive protein, total cholesterol, low-density lipoprotein cholesterol, and triglycerides (P>0.05). However, the treatment had a significant effect on high-density lipoprotein cholesterol [MD=0.05, 95% CI (0.00, 0.09), P=0.04]. Conclusion  Periodontal treatment has good effects on controlling high-density lipo-protein cholesterol although more randomized controlled trials must be conducted to verify its effectiveness.

Key words: periodontal treatment, cardiovascular diseases, periodontitis, Meta-analysis, systematic review