应用磁力矫治器对青春期恒河猴进行Ⅲ类功能牵引的组织形态学观察

doi:10.3969/j.issn.1000-1182.2011.05.019

华西口腔医学杂志

应用磁力矫治器对青春期恒河猴进行Ⅲ类功能牵引的组织形态学观察

赵宁1 徐芸2 陈扬熙3 沈刚1 许艳华2

1.上海交通大学医学院附属第九人民医院正畸科，上海市口腔医学重点实验室，上海200011；2.昆明医学院附属口腔医院正畸科，昆明650031； 3.四川大学华西口腔医院正畸科，成都610041

收稿日期:2011-10-25 修回日期:2011-10-25 出版日期:2011-10-20 发布日期:2011-10-20
通讯作者: 徐芸，Tel：0871-4109203
作者简介:赵宁（1977—），男，山东人，主治医师，博士
基金资助:
云南省自然科学基金资助项目（2002C0023R）

Influence of class Ⅲ magnetic appliances on the craniofacial morphology and histology in Rhesus monkeys

Zhao Ning1, Xu Yun2, Chen Yangxi3, Shen Gang1, Xu Yanhua2

1. Dept. of Orthodontics, The Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China; 2. Dept. of Orthodontics, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming 650031, China; 3. Dept. of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China）

Received:2011-10-25 Revised:2011-10-25 Online:2011-10-20 Published:2011-10-20
Contact: Xu Yun，Tel：0871-4109203

摘要/Abstract

摘要：

目的应用Ⅲ类磁力矫治器建立青春期恒河猴动物模型，观察其对颅面部形态学及颅面骨缝的组织学影响，并探讨其机制。方法选用生长发育期雄性恒河猴6只，实验组45、90 d各2只，对照组45、90 d各1只。实验组配戴铸造式磁力矫治器，对照组不戴用矫治器。采用头颅侧位片测量分析其颅颌面的形态学变化。选用颅面部6条骨缝作为观察对象，应用活体荧光染色及苏木精-伊红染色观察其组织学变化。结果所有实验动物颌位均出现明显近远中移位，90 d组的变化较45 d组更为明显，对照组无明显变化。荧光染色及苏木精-伊红染色观察显示：实验组各骨缝均表现为明显的骨沉积，尤其是颧颌缝、腭横缝、翼腭缝、颧颞缝最为明显。结论Ⅲ类磁力矫治器可以引起上下颌骨以及牙齿位置的变化，并可使颅面骨缝内纤维结缔组织排列方向发生变化，导致骨缝两侧新骨的大量沉积。

关键词: Ⅲ类错, 磁力矫治器, 颅面部骨缝

Abstract:

Objective To investigate the influence of class Ⅲ forces in craniofacial morphology and sutural histology in Rhesus monkeys. Methods Six male Rhesus monkeys in mixed dentition were employed in this study, two as 90-day experimental group, two as 45-day experimental group and the other two as control respectively. The experimental monkeys were casted magnetic orthopedic appliance-Ⅲ（MOA-Ⅲ）, the control monkeys received no treatment. Intraoral photographs, casts and cephalometric radiographs of each animal were obtained at the beginning and at the end of the experiment. Fluorescent and haematoxylin-eosin staining were used to observe the histological changes in craniofacial sutures. Results In experimental groups, the maxillomandibular relationship changed more significantly in 90-day experimental group than 45-day experimental animals. But changes were scarcely noted in the control. The bony depositions of the sutures were distinctly found during the experimental period, especially in zygomaticomaxillary, transverse palatine, pterygopalatine and zygomaticotemporal sutures. Conclusion This study indicates that this kind of magnetic appliance could cause skeletal and dental changes of maxilla and mandible, and change the arrangement of connective tissues in craniofacial sutures, and lead to significant new bone deposition in craniofacial sutures.

Key words: class Ⅲ malocclusion, magnetic appliance, craniofacial sutures

赵宁徐芸陈扬熙沈刚许艳华. 应用磁力矫治器对青春期恒河猴进行Ⅲ类功能牵引的组织形态学观察[J]. 华西口腔医学杂志, doi: 10.3969/j.issn.1000-1182.2011.05.019.

Zhao Ning1, Xu Yun2, Chen Yangxi3, Shen Gang1, Xu Yanhua2. Influence of class Ⅲ magnetic appliances on the craniofacial morphology and histology in Rhesus monkeys[J]. West China Journal of Stomatology, doi: 10.3969/j.issn.1000-1182.2011.05.019.

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应用磁力矫治器对青春期恒河猴进行Ⅲ类功能牵引的组织形态学观察

Influence of class Ⅲ magnetic appliances on the craniofacial morphology and histology in Rhesus monkeys

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